Conversely, HKU4, HKU5 and SARS-CoV 3CLpro enzymes are tightly associated dimers.
Not only is there a shortage of commercial anti-PEDV drugs, but available commercial vaccines fail to protect against highly virulent PEDV variants. There is an urgent need to find new therapeutic methods to prevent and control PEDV.
Anglo-Chinese School(Independent), Singapore. and Isatis Indigotica Root, on 3CLpro from SARS-CoV-2 Using Both Cell-based and Cell-free Assay Models. In the present work, 9101 drugs obtained from the drug bank database were screened against SARS-CoV-2 3CLpro prosing deep learning, molecular docking, and molecular dynamics simulation techniques.
